If you know who John Mulaney is you know part of his act is being super clean, nice, and self deprecating. He starts one of shows off by saying “I at one time did cocaine, yeah, this guy, the guy you see before you”.
He got to have fun playing a real jerk on HBO’s series Crashing. Only problem is he may have done too good of a job and some people think he is actually a big meany.
Conan also had a similar situation where Jenny McCarthy over heard a joke and thought he was really mean too out of context.
They both laugh and discuss this on his TBS show.